The Organizing Committee of the 2nd. Mini Symposium: Implications on Survival and Death Mechanisms for the Interactions of Pathogenic Protozoa with their Hosts welcomes all participants to our one-day meeting in São Paulo. We would like to specially thank all of the invited speakers for their valuable contributions, as well as the participants. This year, we organized the meeting in four Round Tables approaching different topics on the biology of pathogenic protists. We would like to acknowledge also the financial support of the following funding agencies and Institutions: FAPESP, University of São Paulo, Global Challenges Research Funds and University of Edinburgh. We wish all the participants an interesting and productive meeting.
New event location: Departamento de Imunologia
Instituto de Ciências Biomédicas – USP
Edifício Biomédicas IV – Depto. de Imunologia
Av. Prof. Lineu Prestes, 1730
8:30 – 10:30 Round Table 1: Host-Parasite Interactions
Mark Carrington (University of Cambridge, UK): Characterization and exploitation of macromolecular interactions between African Trypanosomes and their mammalian hosts.
Luisa Figueiredo (University of Lisboa, Portugal): Adipose tissue – a safe haven for Trypanosoma brucei.
Carlos Robello (University of the Republic, Uruguay): Transcriptomic analysis of the early response to Trypanosoma cruzi infection reveals wide expression reprogramming in human cells.
10:30 – 11:00 Coffee Break and Poster Session
11:00 –13:00 Round Table 2: Metabolism and metabolic enzymes
Richard Burchmore (University of Glasgow, UK): A defined medium for Leishmania culture allows definition of essential amino acids.
Emma Saavedra (National Institute of Cardiology Ignacio Chavez, Mexico): Metabolic modeling and Control Analysis of Trypanosoma cruzi metabolism for drug target identification.
Wilfredo Quiñones (University Los Andes, Venezuela): Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle of Trypanosoma cruzi.
13:00 – 15:00 Interactive Lunch and Poster Session
15:00 – 17:00 Round Table 3: Genomes, protein expression and genetic manipulation
Otavio H. Thiemann (University of São Paulo, Brazil): Beyond the genetic code. When “Stop” is not the end of the translation.
Jeremy Mottram (University of York – UK): 25 years of Leishmania genetic manipulation: where do we stand on validated drug targets?
Luiz Tosi (University of São Paulo, Brazil): The dual role of HUS1 in maintaining the plastic genome of Leishmania.
17:00 – 17:30: Coffee Break and Poster Session
17:30 – 19:30: Round Table 4: Chemotherapy and Drug Discovery.
Harry de Koning (University of Glasgow, UK): Transporters and drugs: targeting, selectivity and resistance.
Paul Denny (University of Durham, UK): From anti-leishmanial targets to drug discovery, and back again.
Mark Field (University of Dundee, UK): A century of therapeutics against trypanosomes.